Friday, January 24, 2020

Lord Of The Flies Vs. Huck Fin :: essays research papers

Responsibility   Ã‚  Ã‚  Ã‚  Ã‚  In today’s society, human beings must learn to take care of something or someone,and that is a responsibility that they must uphold. In both the Lord of the Flies, and The Adventures of Huckleberry Finn, the responsibility of the boys is to manage by themselves without any adults to take care of them. The events in William Golding’s book Lord of the Flies can be easily compared to those of Mark Twain’s book, The Adventures of Huckleberry Finn, because the main characters both have major responsibilities. There are two responsibilities that the characters came in contact with, taking care of people,including themselves, and being responsible enough to do the right thing. Thus, responsibility helps individuals to evolve and mature.   Ã‚  Ã‚  Ã‚  Ã‚  Taking care of yourself, as well as others is an enormous responsibility. In both books, the main characters must take care of themselves because they do not know who they can trust. The boys in the Lord of the Flies basically have to live their own lives, for they are on an island with no one to run to except themselves, or some of the other boys that they trust. Although, the ones they trust are already fending for themselves. The characters all go through changes as they adjust to their new world, and become different people because of it. In example to this, Jack seems like a strong willed character at the start of the book, but the other boys never would have imagined he would turn into a cold blooded killer. Therefore, they must learn to take care of themselves for they can not depend on Jack or any of the older boys, to be there for each and every one of them. It is proven that each boy has this responsibility in the following quote;   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã¢â‚¬Å"Merridew turned to Ralph. ‘Aren’t there any grown-ups?’ ‘No.’   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Merridew sat down on a trunk and looked round the circle. ‘Then   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  we’ll have to look after ourselves.’† (Golding 17)   Ã‚  Ã‚  Ã‚  Ã‚  This is an immense responsibility for the boys, because they never had to live on their own before they arrived on the island. In The Adventures of Huckleberry Finn, both Jim, the runaway nigger, and Huck choose the responsibility of taking care of themselves. This is because they both run away from the lives they had been living.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã¢â‚¬Å"But looky here, Huck, who wuz it dat ‘uz killed in dat shanty   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  ef it warn’t you?

Thursday, January 16, 2020

Reseach Workoholics Essay

Is a 40-hour work week too much? Should there be a mandatory cap on the number of hours a person can work? Should there be changes in employment laws to give Americans more relaxation time? A workaholic definition is a noun a person who compulsively works hard and long hours. But the definition in a workaholics eyes is a person who â€Å"values work over any other activity†, according to careercast.com. Merriam-webster.com says it’s a â€Å"compulsive worker†Ã¢â‚¬ ¦ (Productivity) The reasons for someone to become a workaholic are some people don’t feel their lives are fulfilled unless they’re engaged in constructive activities. The more they work, the happier they are. It’s addictive. Where in the world can they be productive and reap the rewards of their labor but at their job? Workaholics can’t be idle. They need to be constantly working. Proving their value Children who were raised in dysfunctional families, or by perfectionist parents, and were made to feel like their best was never good enough can grow up to be workaholics. Spending their adult lives immersed in their work is a way for them to constantly prove themselves and their worth. Escaping problems and negative feelings another reason why people become workaholics is because they lack a sense of control in their lives. They have problems at home they can’t fix, or they don’t want to deal with, for example. Being at work all the time allows them to escape painful, negative feelings. It also gives them a sense of control they can’t find otherwise. Adrenaline rush working non-stop provides an adrenaline rush to some people. Being extremely busy, rushing to meet unrealistic goals, and pushing themselves beyond their limits gives them that intense feeling they crave. That same adrenaline rush- the increased heart rate, the burst of energy, the heightening of their senses- comes from roller coaster rides and other thrilling activities. In 1965, a U.S. Senate subcommittee predicted that as a result of increasing labor productivity from automation and â€Å"cybernation† in other words, the computer revolution. Americans would be working only about 20 hours a week by the year 2000, while taking seven weeks or more of vacation a year. By the mid-1970s, and especially after 1980, median wages weren’t keeping pace with increases in our capacity to produce. But flattening incomes didn’t derail the consumption train. Americans continued to buy more, in part by going deeper into debt, by having more members of the family enter the workforce and by working additional overtime. By the boom times of the late 1990s, Americans worked more than the notoriously workaholic Japanese. To answer the question of limiting the number of hours you can work I think we would have a happier and healthier society if we worked a little less. As of right now, some jobs require a lot of time and energy. Legalizing mandating the number of hours worked is an interesting idea. It would see a drop in stress levels, more family time and participation and healthier workers. This probably wouldn’t make too many people happy at first, though, and it would take some getting used to. It is a way to raise healthier families and having less levels of stress that are exhibited in really tough jobs, like ER doctors and nurses, and other highly stressful occupations. American work-life balance according to the Center for American Progress on the topic of work and family life balance, â€Å"in 1960, only 20 percent of mothers worked. Today, 70 percent of American children live in households where all adults are employed.† I don’t care who stays home and who works in terms of gender (work opportunity equality for all – it’s a family choice). Either way, when all adults are working (single or with a partner), that’s a huge hit to the American family and free-time in the American household. The U.S. is the ONLY country in the Americas without a national paid parental leave benefit. The average is over 12 weeks of paid leave anywhere other than Europe and over 20 weeks in Europe. Zero industrialized nations are without a mandatory option for new parents to take parental leave. That is, except for the United States. Let’s say someone make $60k/year. Excluding benefits, employee taxes, etc., let’s consider this equivalent to $30/hour. ($30/hour x 40 hours x 50 weeks = $60k). Now they want to figure out the hourly number that he/she use to decide if it’s worth it to do something. For example, if he/she owe a fine on something he/she don’t think they should owe, but it’s only a $5 fine, it’s not worth spending an hour ($30) to contest it. BUT, it’s not clear to me if he/she should use $30/hour for this number, because I’m only working 8 hours/day. Like, if someone is willing to pay me for 40 hours/week at $30/hour, presumably he/she could get one or two more such jobs. Or should she/he divide that by 3 to get $10/hour because really for every 24 hours, they’re only â€Å"able† to earn $30/hour for a third of them? Because some of these activities he/she would be doing in my off-hours (e.g., they’d have to dispute that fine after work). Or is it something in between?

Wednesday, January 8, 2020

Essay about Case Study - 1128 Words

ISyE 6203 Transportation and Supply Chain` Systems Spring 2013 Case Study: Arc Routing The Bridges of Konigsberg 1) Was there ever a date at which an Eulerian walk over the steel bridges of Konigsberg were possible, without using any wooden bridges? If so, when? If not, show that it was never possible. For a Eulerian walk to be possible two conditions must hold a) The undirected graph must be connected b) Each node must be of even degree. Name of the bridge | Date built | Honey Bridge (7) | 1879-1882 | Slaughter Bridge (3) | 1886 | Blacksmith’s Bridge (4) | 1896 | Salesman Bridge (1) | 1900 | Timber Bridge (5) | 1904 | Emperor’s bridge (8) | 1905 | Green Bridge (2) | 1907 | High Bridge (6) | 1937 |†¦show more content†¦2) What idealized arc routing problems have been used for roadway snow and ice control? Idealized models treat RSIC problems as a variant of a) Chinese Postman Problem b) Rural postman problem c) Capacitated Arc Routing Problem d) Sometimes node routing problem instead of arc routing problem 3) What reasons are given for the problems encountered when attempting to implement routing software for roadway snow and ice control? Inability to consider all the nuances of real world operations. Poor implementation and user unfriendly software, distrust of computer based (black box) approaches by public work personnel, unappreciated operational complexities. 4) What beneï ¬ ts were contributed by early roadway snow and ice control software? They focussed attention on savings from better routes. They recogonized the importance of savings from using a rational and analytical approach to fleet size and service level. For eg., the SnowMaster system provided a major advance in the trend towards optimization by encouraging user involvement in route design. 5) Explain the relationship between the duration of a route and the service level provided to the road segments on the route. Service level is the time limit for traversing a route. Trucks usually travel at 20 mph while servicing and 40 mph while deadheading. So, it might not be possible to satisfy a route which is very long. The service level canShow MoreRelatedCase Studies : A Case Study Approach Essay1157 Words   |  5 PagesA case study is a specific instance that is frequently designed to illustrate a more general principle (Nisbet and Watt, 1984). Hitchock and Hughes (1995) further suggest that the case study approach is particularly valuable when the researcher has little control over evens. Case studies strives to portray ‘what it like’ to be a particular situation, to catch up reality and ‘thick description’ (Geertz, 1973) of participants’ lives experiences of, thoughts about and feelings for a situation. TheyRead MoreCase Study887 Words   |  4 PagesCHAPTER I INTRODUCTION 1.1 Reasons choose the case 1.2 The Problems The problems of this case are: 1. How would you characterize Lincoln Electric’s strategy? In this context, what is the nature of Lincoln’s business and upon what bases does this company compete? 2. What are the most important elements of Lincoln’s overall approach to organization and control that help explain why this company is so successful? How well do Lincoln’s organization and control mechanismsRead MoreBusiness Case Study : Business Case Studies997 Words   |  4 PagesWriting Business Case Studies How to Write Business Case Studies The objective of this part of the course is to use your case study to help you solve real company problems and to make the learning more relevant to your experience. The Business Case Study you are being asked to start today will provide information for yourself and the class to permit constructive feedback. You will have to use all of your research, writing and analytical skills to write your Company Case Study. You must give enoughRead MoreCase Study148348 Words   |  594 Pages978-0-273-73552-6 (web) All rights reserved. Permission is hereby given for the material in this publication to be reproduced for OHP transparencies and student handouts, without express permission of the Publishers, for educational purposes only. In all other cases, no part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without either the prior written permission of the Publishers orRead MoreCase Studies13817 Words   |  56 PagesCASE STUDY #1 A Job Search Dilemma Eric, a second-semester senior, is looking for a job. Anxious about finding work in the worst economy in decades, he sends out scores of resumes for a wide variety of positions. The first call he gets is for a position that doesnt really interest him, but he figures he should be open to every opportunity. He schedules an interview, which he aces. In fact, the recruiter offers Eric the job on the spot. He would like Eric to start as soon as possible. Should EricRead MoreCase Study 8985 Words   |  4 PagesCase Study 8 Based on the January through June 2010 cash budget, what is the maximum monthly loss during the six-month planning period? What is the maximum cumulative borrowing balance? (For purposes of this question, disregard any interest payments on short-term bank loans or interest received from investing surplus funds.) Maximum monthly loss is in June: -$60,750. The maximum cumulative borrowing balance is $99,000 in February. What does the monthly cash budget reveal that indicatesRead MoreCase Study : The Angel 1089 Words   |  5 Pages Case Study #1 The Angel, 1997 Susan Meeks, an alias, woke to what she thought was the middle of the afternoon. A bright yellowish light was shining through the west window of her travel trailer. An other world being was in the room and was as tall as the ceiling of the trailer. She went to the bathroom where she washed her face with cold water and stayed in there long enough to smoke a cigarette. When she went back to the bedroom the being was still there. The being showed her futureRead MoreThe Case Study Of The Company1468 Words   |  6 PagesOverview of Case Study In the case study by Spector titled, Transferring Innovation Across National Boundaries, (Spector, 2012) company named Minnesota Biolabs (MB) provided laboratories with a quality test for contamination of injectable medications. This test required the use of live rabbits that led to the rabbit’s death after the test. The company was headquartered in Minneapolis, however they were organized with four, somewhat independent, national units in Europe and Japan, each run by aRead MoreLaw of Case Studies1514 Words   |  7 PagesZulfatah Arif SCM-019741 Work Psychology in Communication, Writing and Reporting COM 2153 Mr Haji Adenan Case Studies An Unmotivated Building Inspector Case Study By: Zulfatah Arif 1) Review the motivation theories discussed in this chapter. How would each one describe and explain the problems with Simon Lucas’s motivation? The theories that would be relevant to the problems with Simon Lucas’ motivation would be the McClelland’s Need Theory and Herzberg’s Two-Factor Theory.Read MoreCase Study Essay1116 Words   |  5 PagesCase Study Objective The Case will focus on issues related to the cultural aspect of international business; sustainable business practices including CSR issues; foreign investment; and the benefits of regional integration for the countries within, and companies doing business in, that region.   The case study analysis will be completed on an individual basis. Instructions THE CASE: Kaizer Consulting Kaizer Consulting is an international management consulting firm that specializes in business strategy

Tuesday, December 31, 2019

Compare and Contrast Women at Home in Ww1 and Ww2

Compare and contrast the role of women at home during World War I and World War II. Before World War I and World War II, women at home had the roles of maintaining duties for their family and children, such as cleaning, caring for the house, and cooking for the family. They were more likely judged by their exquisiteness rather than their ability. Just before World War I began, women were beginning to break away from the traditional roles they had played at home. Throughout both World Wars, women in the United States faced similar challenges, however, during the Second World War; women were trusted with much more freedom and responsibility than they had in the First World War. In comparison, the first and second World Wars†¦show more content†¦At the time of World War one, the Young Women Christian Association (YWCA), Patriotic League, and the Red Cross organizations were made to help the war efforts. The Red Cross for example, allowed women to work and help the war effort as nurses. As women were not seen to work in higher praised jobs that only men could do, they proved themselves to be as skilled if not more during World War one. Women worked in industries and their development was drastically spoken about in newspapers and articles. There successes and skilled efforts was commended and was beginning to change the minds of men who thought women were incapable. Women, during World War one, replaced men in skillful jobs such as railroad workers, and other machine operators. During the beginning of World War one, women were seen as incapable of holding professional jobs that men took. However, demonstrating their efforts in factories and hel ping the war effort showed the capability of women to work in any job that was traditionally for women. Throughout World War one, women gained the positions of being doctors, lawyers, and bankers. These job opportunities during World War one gave women a chance to show the male-dominated society that they were proficient and were able to more than staying at home and raising their children. Throughout World War one, women had played a vital role in helping the war and its soldiers. Women also played a key role in helping the

Monday, December 23, 2019

The Life And Works Of Sigmund Freud Essay - 1679 Words

The life and works of Sigmund Freud Introduction Sigmund, an Austrian national, was born in Moravia hamlet of Freiberg, Germany on May 06, 1856 and died in London, England on September23, 1939. He was born in the era of â€Å"logic and reason† (Love and the formations of family) when sciences was all that mattered and rational analysis was perceived as being the answer to all â€Å"mysteries† (Love and the formation of family). At the age of three his family relocated to Austria where he lived until the last year of his life (World of health, 2007). He was admitted into the medical school at the age of 17 where he conducted a lot of research works. Even though his major interest was in researches on physiology, he was made to conduct some clinical practice because of the â€Å"difficulty of obtaining a university appointment—aggravated, in his case, by anti-Semitic attitudes and policies.† (Lerner et al, 2006) Freud conducted a lot of independent research and clinical work† and had his own practi ce where his area of specialty was treating patients with neurological and hysterical conditions (Lerner et al 2006). Freud’s mentor and colleague, Josef Breuer, once had a cathartic treatment of â€Å"hysterical symptoms,† a condition that was observed to vanish when a patient reminiscences a traumatic incident when under hypnosis and was able to demonstrate the initial response that he had â€Å"repressed and forgotten.† Freud spent several months in France experimenting on this idea by studyingShow MoreRelatedEssay on Sigmund Freud: His Life And His Work2990 Words   |  12 Pages Sigmund Freud was born on May 6th 1856 in Freiberg, Moravia, which is now in Czech Republic. He is the eldest of eight children born to Jacob and Amalie Freud. Because of the anti-semetic riots who were ragging in Freiberg , Freud’s father, who was a wool merchant, lost his business and the whole family had to move to Leipzig (1859) and shortly after to Vienna where Freud s pend most of his life. When he lived in Vienna, Freud had, once more, to come accross anti-semetism : jewish people had beenRead MoreSigmund Freud s Life Of Psychology And Psychoanalysis1330 Words   |  6 PagesMy life is interesting only if is related to psychoanalysis said Sigmund Freud, a pioneer in the world of psychology and psychoanalysis (Sigmund Freud - Life and Work.). Freud had a passion for the mind. Not just the mind of the average man but also the minds of the sick and tortured souls. He built his life around knowledge and manipulation of others minds to give them peace and reach understanding. Though he has been condemned as a cult leader and a fraud, Sigmund Freud is undisputedly theRead MoreSigmund Freud s Theory Of Psychoanalysis1339 Words   |  6 PagesSigmund Freud Biographic Description of Sigmund Freud Sigmund Freud was born on May 6, 1856 in Freiberg (currently known as Czech Republic). Freud is best known as the founder of psychoanalysis, which entails a scientific analysis of unpacking unconscious conflicts based on free associations, fantasies, and dreams of the patient. He was among the greatest psychologists of the 20th century, and his legacy lasts up to now. While young (4 years old), his family relocated to Vienna where he lived andRead MoreSigmund Freud Essay1721 Words   |  7 Pagesâ€Å"Man is a wolf to man.† These are the words that surprised millions when Freud first opened the discussion of human nature (Freud). Sigmund Freud, born in 1856 and died in 1939, was known to be the father of psychoanalysis (Jones). He lived his whole life trying to reach into the human unconsciousness and unravel the puzzle of life, human personality, and human nature (Chiriac). Sigmund Freud was influenced by the environment post World War I, and influenced the world through his theories and hisRead MoreMoore 1. Kristen Moore. Mrs. Kristy French. English Iii1443 Words   |  6 Pagescentury psychologist named Sigmund Freud. Freud published a myriad of theories regarding the human mind and its inner workings, which have since fallen from practice. A great majority of his theories have been disproven and rendered useless, though his name is one that is immediately recognized upon mention and he is one of the first figures that psychology majors study. If Freud has fallen from practice, however, why are his theories still studied at all? Although Sigmund Freud’s practices and theoriesRead MoreEssay about Sigmund Frueds Psychology1339 Words   |  6 PagesSigmund Freud was born in 1856 in Frieber, Moravia; his father was a wool merchant and his mother was twenty years younger than his father. Freud had two step brothers which were around the same age as his mother; one stepbrother had a son who became Freud’s playmate growing up (Sigmund). Around the age of four, Freud and his family moved to Vienna where he stayed for a majority of his life. (Boeree) When Freud’s family moved to Vienna, they lived in an area that was highly populated with JewsRead MoreSigmund Freud. Briana Gates. Mr. Wiles. Psyc 43101-01:1611 Words   |  7 Pages Sigmund Freud Briana Gates Mr. Wiles PSYC 43101-01: History and Systems of Psychology February 25, 2017 On May 6, 1856, a baby by the name of Sigmund Freud was born, in a what is now known as the Czech Republic (Schultz Schultz, 2012). After moving around a bit, Freud eventually settled in Vienna, and spent most his life there. It is without question that Sigmund Freud is a well-known name, and that he can be considered the father of what is known as psychoanalysis, seeing as how heRead MoreFreud and Jungs Father/Son Relationship835 Words   |  4 PagesFreudJung Introduction The relationship between Carl Jung and Sigmund Freud began in 1906 when Jung sent Freud a signed copy of his published studies. Unknown to Jung, Freud had already purchased his own copy of the book after hearing how favorably his name figured into the writings. Six months later, Freud sent a collection of his latest published essays to Jung in Zà ¼rich.(The Well-Documented Friendship of Carl Jung Sigmund Freud, 2014,p.1) When the two were finally able to meetRead More Sigmund Freuds Influence upon Salvador Dali Essay1591 Words   |  7 Pagesinventors, and scientists were reveling on new ways of experiencing life. The shadows of the past and the dawn of the new era opened the minds of many who relished constant change. Science and medicine were evolving, and one man in particular sought to expand knowledge and understanding. Sigmund Freud, the most renowned, thought provoking psychologist to have ever lived, opened an exciting chapter in the study of the mind. Without a doubt, Freud had influenced, and inspired artists searching for somethingRead MoreFreud And The Czech Republic1159 Words   |  5 PagesFreud was born in the Czech Republic on May 6th, 1856. At a young age his family moved to Vienna, in which, he spent most of his life there. He received his medical degree in 1881 from the University of Vienna and married in the following year. He had six children and his youngest, Anna Freud, had d ecided to become like her father. In which she continued and explored his work until her death in 1982. Freud had set up a private practice and treated people with a wide verity of psychological disorders

Sunday, December 15, 2019

Week 5 Quizzes †Eco/Gm 561 Free Essays

Week 5 Quizzes ECO/GM 561 Your Results for: â€Å"Readiness Assessment Quiz†Print this page Site Title:Economics UOP custom CW Book Title:UOP-custom course for Economics Book Author:Case Summary of Results 100% Correct of 7 Scored items: 7 Correct: 100% 0 Incorrect: 0% More information about scoring ________________________________________ 1. GDP includes all transactions in which money or goods change hands. Your Answer:False ________________________________________ 2. We will write a custom essay sample on Week 5 Quizzes – Eco/Gm 561 or any similar topic only for you Order Now GDP is equal to the value of total sales in an economy. Your Answer:False _______________________________________ 3. I bought a record last year. I don’t like it any more and am going to sell it to my cousin for $2. This sale should be included in GDP. Your Answer:False ________________________________________ 4. Consumption, investment, government purchases, and net exports are the four components of total expenditures. Your Answer:True ________________________________________ 5. Households have all of their personal income to spend or save. Your Answer:False ________________________________________ 6. When economists calculate nominal GDP it means they are calculating GDP only approximately. Your Answer:False ________________________________________ 7. Per capital GDP is a country’s GDP divided by its population. Your Answer:True ________________________________________ Your Results for: â€Å"Readiness Assessment Quiz†Print this page Site Title:Economics UOP custom CW Book Title:UOP-custom course for Economics Summary of Results 100% Correct of 8 Scored items: 8 Correct: 100% 0 Incorrect: 0% More information about scoring ________________________________________ . The twin evils of macroeconomics are unemployment and inflation. Your Answer:True ________________________________________ 2. Recessions last six months. Anything longer is called a depression. Your Answer:False ________________________________________ 3. To be considered employed a person must be working for pay for at least 20 hours per week. Your Answer:False ________________________________________ 4. You need to be 14 years old to be considered part of the labor force. Your Answer:False ________________________________________ . A discouraged worker is not actually working. Your Answer:True ________________________________________ 6. People typically are unemployed for at least six months. Your Answer:False ________________________________________ 7. Recessions have a good side to them because they help reduce inflation. Your Answer:True ________________________________________ 8. The consumer price index is based on a bundle of goods and services purchased yearly by the typical urban consumer. Your Answer:False ________________________________________ How to cite Week 5 Quizzes – Eco/Gm 561, Papers

Friday, December 6, 2019

Extended Response Case Study-Free-Samples for Students-Myassignment

Question: Taking into account the role of the myelin sheath and the nodes of Ranvier, explain how APs are propagated along an axon, in a healthy subject, and how this is changed in MS. Answer: Nervous System The axons of neurons often are myelinated i.e. they are wrapped around by a sheath of myelin. Myelin is a protein-lipid complex, which is formed by Schwan Cells of in the Central Nervous System when they wrap their membrane around the axon, eventually locked together by a membrane protein, P0. Nodes of Ranvier are the portions of the axon that are not being enveloped by the myelin i.e. these about 1m periodic gaps of separated by 1mm are unmyelinated. Myelin acts as insulation to nerve impulse conduction. Nerve impulses are sent between neurons which is the only mode of communication for the nervous system. Electronic potentials that can produce propagated disturbances are called action potentials or nerve impulses. The nerve impulses are produced due to change in ionic conduction across the cell membrane of the neurons. The potential of nerve cells are found to be negative inside relative to outside; it is about -70mV. When the neuron is stimulated a series of potential changes occu r across its membrane and the stimulus thus propagates through the axon to another adjacent neuron. Depolarization increases the membrane potential to +35mV and again reverses and falls rapidly causing to reach the resting depolarized state. In unmyelinated nerve fibres local circuits of ion current are produced in the active regions of the neuron which is stimulated; the local circuit thus produced can depolarize the adjacent part of the membrane which continues in s sequential fashion (Arancibia-Carcamo Attwell, 2014). Conversely, in myelinated neurons ion exchange is allowed only at the Nodes of Ranvier and rest of the axon is insulated by myelin itself. This increases the speed of transmission of impulse through the axon. When an impulse reaches a Node of Ranvier it cannot flow through the high-resistance myelin sheath instead depolarizes the membrane at the next Node of Ranvier about 1mm away from it. Thus myelin increases the length constant i.e. the distance an ion travels before leaking out of the membrane by increasing the membrane resistance and thus resulting in insulation of the neuron. Further myelin decreases the capacitance of the membrane by separating the opposite charges across the two sides of the mem brane by a considerable distance. Thus in myelinated neurons impulse flows in a jumping fashion from one Node to the next which is termed as Saltatory Conduction. Multiple Sclerosis is an idiopathic, autoimmune, inflammatory disorder of the Central Nervous System that causes patchy destruction of the myelin sheath of the neurons. The destruction of the myelin sheath results in delayed or blocked conduction of impulses through the affected neurons leading to several neurodegenerative symptoms. Further the damage of myelin causes patches of scar tissues at various regions of the Brain and Spinal Cord and hence the name Multiple Sclerosis (Scleroses meaning scar tissue) (Dendrou, Fugger Friese, 2015). The impairment of nerve impulse conduction can affect physiological functions such as movement, speech or sight. Diagnosis at early stages of the disease prognosis is very difficult which causes delay in commencement of treatment. Endocrine System Metabolism is one of the most significant physiological processes necessary for the sustenance if life. Each and every cell of the human body undergoes various levels of metabolism to perform the fundamental bodily functions. Thyroid gland plays a key role in this context by regulating the level of metabolism in the cells required for the optimal functioning of the same. The hormones secreted by the thyroid gland are Thyroxine (T4) and triiodothyronine (T4), which primarily regulates the oxygen consumption of cells, lipid and carbohydrate metabolism, thermogenesis, growth and nervous system development. Thus they play a pivotal role in growth and maturity and deregulation of the hormone levels can lead to severe disorders. Hence, the hormone secretion is intensely regulated to maintain normal body functioning. Thyroid stimulating hormone or Thyrotropin secreted from the anterior pituitary regulates the secretion of the thyroid gland. It is a tropic hormone and secretion of Thyrotropi n in turn is regulated by Thyrotropin releasing hormone secreted from the paraventricular nucleus of the hypothalamus. Circulating thyroid hormones have feedback effects at hypothalamic and pituitary levels thus completing the Hypothalamus pituitary thyroid axis to maintain optimum levels of both the thyroid hormones in circulating blood (Ortiga?Carvalho, Chiamolera, Pazos?Moura Wondisford, 2016). Increased secretion and hence occurrence of thyroid hormones in the circulating blood results in decreased secretion of Thyrotropin and Thyrotropin releasing hormone and the opposite occurs when thyroid hormones levels are low in circulating blood. Thyroid hormones levels are maintained at a very narrow range by the three glands, failure of any of them causes excess or too less production of thyroid hormones resulting in hyperthyroidism or hypothyroidism respectively. However, the state of normal functioning of the thyroid gland is known as euthyroidism. Hypothyroidism, generally called Myxedema in adults can be caused by a number of diseases of the thyroid gland or can be secondary effects of pituitary gland or hypothalamus dysfunction. In case of pituitary hypothyroidism and hypothalamic hypothyroidism the patient responds to a dose of Thyroid stimulating hormone or Thyroxin; but in can of thyroid gland dysfunction no response to Thyroxin is obtained (Pearce et al., 2013). Symptoms of hypothyroidism may include markedly decreased basal metabolic rate, coarse and sparse hair, dry and yellow skin and low tolerance of cold. Hyperthyroidism is more common in women than in men and is often caused by self-antibodies that stimulate the receptor for thyroid hormones. This results in non-functioning of thyroid hormone in spite of being present in the circulating blood. Both the thyroid hormone secretion are substantially increased and due to over activity of the thyroid gland, it gets enlarged leading to a condition called Goitre (Biondi et al., 2015). However, as thyroid hormone levels remain adequate in the circulating blood Thyroid stimulating hormone is maintained at a low level due to feedback inhibition of the same. Some of the significant symptoms of hyperthyroidism are weight loss, low tolerance of heat, increased blood pressure, and a markedly increase in the basal metabolic rate of the body. References Ortiga?Carvalho, T. M., Chiamolera, M. I., Pazos?Moura, C. C., Wondisford, F. E. (2016). Hypothalamus?Pituitary?Thyroid Axis.Comprehensive Physiology. Pearce, S. H., Brabant, G., Duntas, L. H., Monzani, F., Peeters, R. P., Razvi, S., Wemeau, J. L. (2013). 2013 ETA guideline: management of subclinical hypothyroidism.European thyroid journal,2(4), 215-228. Biondi, B., Bartalena, L., Cooper, D. S., Hegeds, L., Laurberg, P., Kahaly, G. J. (2015). The 2015 European Thyroid Association guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism.European thyroid journal,4(3), 149-163. Arancibia-Carcamo, I. L., Attwell, D. (2014). The node of Ranvier in CNS pathology.Acta neuropathologica,128(2), 161-175. Dendrou, C. A., Fugger, L., Friese, M. A. (2015). Immunopathology of multiple sclerosis.Nature reviews. Immunology,15(9), 545.